Showing posts with label The Big Picture of coronavirus and other viruses. Show all posts
Showing posts with label The Big Picture of coronavirus and other viruses. Show all posts

Saturday, May 15, 2021

g-f(2)277 The Big Picture of the Digital Age (5/15/2021), AAAS, Investigate the origins of COVID-19.



Extra-condensed knowledge


  • More investigation is still needed to determine the origin of the pandemic. 
    • Theories of accidental release from a lab and zoonotic spillover both remain viable. Knowing how COVID-19 emerged is critical for informing global strategies to mitigate the risk of future outbreaks.
  • As scientists with relevant expertise, we agree with the WHO director-general, the United States and 13 other countries, and the European Union that greater clarity about the origins of this pandemic is necessary and feasible to achieve.
    • We must take hypotheses about both natural and laboratory spillovers seriously until we have sufficient data.
  • A proper investigation should be transparent, objective, data-driven, inclusive of broad expertise, subject to independent oversight, and responsibly managed to minimize the impact of conflicts of interest.
    • Public health agencies and research laboratories alike need to open their records to the public. 
    • Investigators should document the veracity and provenance of data from which analyses are conducted and conclusions drawn, so that analyses are reproducible by independent experts.

ULTRA-condensed knowledge


ALERT, AAAS,
  • Knowing how COVID-19 emerged is critical for informing global strategies to mitigate the risk of future outbreaks.


Genioux knowledge fact condensed as an image


Condensed knowledge


  • More investigation is still needed to determine the origin of the pandemic. 
    • Theories of accidental release from a lab and zoonotic spillover both remain viable. Knowing how COVID-19 emerged is critical for informing global strategies to mitigate the risk of future outbreaks.
  • As scientists with relevant expertise, we agree with the WHO director-general, the United States and 13 other countries, and the European Union that greater clarity about the origins of this pandemic is necessary and feasible to achieve.
    • We must take hypotheses about both natural and laboratory spillovers seriously until we have sufficient data.
  • A proper investigation should be transparent, objective, data-driven, inclusive of broad expertise, subject to independent oversight, and responsibly managed to minimize the impact of conflicts of interest.
    • Public health agencies and research laboratories alike need to open their records to the public. 
    • Investigators should document the veracity and provenance of data from which analyses are conducted and conclusions drawn, so that analyses are reproducible by independent experts.

Category 4: The Big Picture of coronavirus and other viruses

[genioux fact deduced or extracted from AAAS]

This is a “genioux fact fast solution.”


ALERT, AAAS,
  • Knowing how COVID-19 emerged is critical for informing global strategies to mitigate the risk of future outbreaks.

Type of essential knowledge of this “genioux fact”: Essential Analyzed Knowledge (EAK).

Type of validity of the "genioux fact". 

  • Inherited from sources + Supported by the knowledge of one or more experts + Supported by research.


Authors of the genioux fact

Fernando Machuca


References


Investigate the origins of COVID-19, 18 scientists, May 14, 2021, Vol. 372, Issue 6543, pp. 694 DOI: 10.1126/science.abj0016, American Association for the Advancement of Science, AAAS.


ABOUT THE AUTHORS


The 18 scientists

  1. Jesse D. Bloom, 
  2. Yujia Alina Chan, 
  3. Ralph S. Baric, 
  4. Pamela J. Bjorkman, 
  5. Sarah Cobey, 
  6. Benjamin E. Deverman, 
  7. David N. Fisman, 
  8. Ravindra Gupta, 
  9. Akiko Iwasaki, 
  10. Marc Lipsitch, 
  11. Ruslan Medzhitov, 
  12. Richard A. Neher, 
  13. Rasmus Nielsen, 
  14. Nick Patterson, 
  15. Tim Stearns, 
  16. Erik van Nimwegen, 
  17. Michael Worobey, 
  18. David A. Relman

Extracted from Wikipedia


The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the betterment of all humanity. It is the world's largest general scientific society, with over 120,000 members, and is the publisher of the well-known scientific journal Science.



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Monday, May 3, 2021

g-f(2)259 The Big Picture of the Digital Age (5/3/2021), HBR, The CEO of Pfizer on Developing a Vaccine in Record Time.




Extra-condensed knowledge


First and most important lesson learned, success is a team effort. Every single person in our company and at BioNTech—from senior executives to manufacturing and transportation staffers—was instrumental in the development of our vaccine. 
  • The pandemic was the ultimate test of the pharmaceutical industry’s credibility and relevance, and in my view, the industry passed with flying colors. 
  • We have proved that we’re a group of vibrant companies willing and able to mobilize our exceptionally talented workforces and marshal all other resources to solve a life-or-death problem.
  • I see a bright future for Pfizer. Messenger RNA technology is poised to revolutionize vaccines, and we and BioNTech have a competitive edge. Our other business units also continue to thrive. 
  • Throughout my career at Pfizer, I’ve seen our people do extraordinary things when motivated.


Genioux knowledge fact condensed as an image


Condensed knowledge



Category 2: The Big Picture of the Digital Age

[genioux fact deduced or extracted from HBR]

This is a “genioux fact fast solution.”

Type of essential knowledge of this “genioux fact”: Essential Analyzed Knowledge (EAK).

Type of validity of the "genioux fact". 

  • Inherited from sources + Supported by the knowledge of one or more experts + Supported by research.


Authors of the genioux fact

Fernando Machuca


References




ABOUT THE AUTHORS



Albert Bourla (born October 21, 1961) is a Greek veterinarian and the chairman and chief executive officer of Pfizer, an American pharmaceutical company. He joined the company in 1993 and has held several executive roles across Pfizer's divisions. Prior to becoming chief executive officer, Bourla served as chief operating officer.

In addition to the boards of Pfizer and the Pfizer Foundation, he serves or has served on the boards of the Biotechnology Innovation Organization, Catalyst, the Partnership for New York City, and the Pharmaceutical Research and Manufacturers of America. Bourla is also a member of The Business Council and the Business Roundtable. He engages often with business and health leaders such as Bill Gates.

Bourla was motivated by an early love for animals and medicine and is credited with reshaping Pfizer to be a company focused on research and development and branded patent-protected prescription drugs. He is also credited with helping the development of Improvac, which eradicates boar taint, and for refocusing Pfizer's vaccine division to focus on staphylococcus, clostridioides difficile infection, infant diseases, and the Pfizer–BioNTech COVID-19 vaccine. He opposes government interference in pharmaceutical pricing, which he believes would hamper spending on development of new drugs.


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Friday, February 19, 2021

g-f(2)129 THE BIG PICTURE OF THE DIGITAL AGE, WSJ, Marty Makary, We’ll Have Herd Immunity by April.


VIRAL KNOWLEDGE: The “genioux facts” knowledge news




Extra-condensed knowledge


  • Amid the dire Covid warnings, one crucial fact has been largely ignored: Cases are down 77% over the past six weeks. 
    • If a medication slashed cases by 77%, we’d call it a miracle pill. Why is the number of cases plummeting much faster than experts predicted?
    • In large part because natural immunity from prior infection is far more common than can be measured by testing.
  • Applying a time-weighted case capture average of 1 in 6.5 to the cumulative 28 million confirmed cases would mean about 55% of Americans have natural immunity.
    • Former Food and Drug Commissioner Scott Gottlieb estimates 250 million doses will have been delivered to some 150 million people by the end of March.
    • There is reason to think the country is racing toward an extremely low level of infection. 
  • At the current trajectory, I expect Covid will be mostly gone by April, allowing Americans to resume normal life.


Genioux knowledge fact condensed as an image


Condensed knowledge 


  • Dr. Makary is a professor at the Johns Hopkins School of Medicine and Bloomberg School of Public Health, chief medical adviser to Sesame Care, and author of “The Price We Pay.”
    • My prediction that Covid-19 will be mostly gone by April is based on laboratory data, mathematical data, published literature and conversations with experts. 
    • Herd immunity has been well-documented in the Brazilian city of Manaus, where researchers in the Lancet reported the prevalence of prior Covid-19 infection to be 76%, resulting in a significant slowing of the infection. 

Category 2: The Big Picture of the Digital Age

[genioux fact produced, deduced or extracted from WSJ]

Type of essential knowledge of this “genioux fact”: Essential Deduced and Extracted Knowledge (EDEK).

Type of validity of the "genioux fact". 

  • Inherited from sources + Supported by the knowledge of one or more experts + Supported by research.


Authors of the genioux fact

Fernando Machuca


References




ABOUT THE AUTHORS


Dr. Marty Makary is a professor at the Johns Hopkins School of Medicine and Bloomberg School of Public Health, chief medical adviser to Sesame Care, and author of “The Price We Pay.”


Martin "Marty" Makary is an American surgeon, New York Times bestselling author, and Johns Hopkins health policy expert. 
  • He has written for The Wall Street Journal, USA Today, TIME, Newsweek, and CNN, and appears on NBC and Fox News. 
  • He is the author of The Price We Pay, a book about how business leaders and families can lower their health care costs and the grass-roots movement to restore medicine to its mission. 
  • Dr. Makary practices surgical oncology and gastrointestinal surgery at the Johns Hopkins Hospital and teaches public health policy at the Johns Hopkins Bloomberg School of Public Health. 
  • Makary works in health care innovation, quality measurement science, frail and vulnerable populations, and public health disparities. 
  • He served in leadership roles at the United Nations World Health Organization for the Safe Surgery Saves Lives initiative. 
  • Makary was named one of the most influential people in healthcare by Health Magazine. 
  • In 2018, Makary was elected to the National Academy of Medicine.
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Wednesday, February 17, 2021

g-f(2)124 THE BIG PICTURE OF THE DIGITAL AGE, WSJ, Symptomatic Covid-19 Cases Dropped 94% With Pfizer Vaccine, Israeli Data Show.


VIRAL KNOWLEDGE: The “genioux facts” knowledge news




Extra-condensed knowledge


  • This knowledge could have an extraordinary positive impact in the fight against the pandemic.
  • This knowledge has the potential of becoming g-f Exponential Transformative Knowledge.
    • The latest data from Israel shows a 94% drop in symptomatic Covid-19 infections among 600,000 people who received two doses of Pfizer Inc. and BioNTech SE’s vaccine, offering important new insights for other countries as they roll out their own campaigns.
    • The vaccinated group was also 92% less likely to develop severe illness from the disease, according to a study by Clalit, Israel’s largest healthcare provider.
    • Clalit said the study, which was carried out with a team from Harvard University, included 430,000 people who were between 16 and 59 years of age, and 170,000 who were 60 or older. 
    • Israel leads the world in vaccinating against Covid-19 in terms of percentage of the total population inoculated, has already administered the first shot of a recommended two-dose regimen to about 42% of its roughly nine million population since beginning its program on Dec. 20. About 28% of the entire population is fully vaccinated, according to data from Israel’s health ministry.


Genioux knowledge fact condensed as an image


Category 2: The Big Picture of the Digital Age

[genioux fact produced, deduced or extracted from WSJ]

Type of essential knowledge of this “genioux fact”: Essential Analyzed Knowledge (EAK).

Type of validity of the "genioux fact". 

  • Inherited from sources + Supported by the knowledge of one or more experts + Supported by a study.


Authors of the genioux fact

Fernando Machuca


References




ABOUT THE AUTHORS

News Assistant, The Wall Street Journal
Twitter account: @DovLieber

Dov Lieber is the News Assistant responsible for Israel and the Palestinian Territories, based in Tel Aviv.
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Monday, January 25, 2021

g-f(2)91 THE BIG PICTURE OF THE DIGITAL AGE, NYT, China Wanted to Show Off Its Vaccines. It’s Backfiring.


VIRAL KNOWLEDGE: The “genioux facts” knowledge news




Extra-condensed knowledge

NYT. China Wanted to Show Off Its Vaccines. It’s Backfiring.
  • Delays, inconsistent data, spotty disclosures and the country’s attacks on Western rivals have marred its ambitious effort to portray itself as a leader in global health.
  • China’s coronavirus vaccines were supposed to deliver a geopolitical win that showcased the country’s scientific prowess and generosity. Instead, in some places, they have set off a backlash.
  • China remains on a par with the United States in the number of vaccines approved for emergency use or in late-stage trials.


Genioux knowledge fact condensed as an image


The “genioux facts” Knowledge Big Picture (g-f KBP) charts


The “genioux facts” Knowledge Big Picture (g-f KBP) standard chart


The “genioux facts” Knowledge Big Picture (g-f KBP) graphic


Condensed knowledge  

  • NYT. China Wanted to Show Off Its Vaccines. It’s Backfiring.
    • Delays, inconsistent data, spotty disclosures and the country’s attacks on Western rivals have marred its ambitious effort to portray itself as a leader in global health.
    • China’s coronavirus vaccines were supposed to deliver a geopolitical win that showcased the country’s scientific prowess and generosity. Instead, in some places, they have set off a backlash.
    • China remains on a par with the United States in the number of vaccines approved for emergency use or in late-stage trials. 
    • Officials in Brazil and Turkey have complained that Chinese companies have been slow to ship the doses and ingredients.
    • Disclosures about the Chinese vaccines have been slow and spotty. The few announcements that have trickled out suggest that China’s vaccines, while considered effective, cannot stop the virus as well as those developed by Pfizer and Moderna, the American drugmakers.
    • Beijing officials who had hoped the vaccines would burnish China’s global reputation are now on the defensive.
    • At least 24 countries, most of them low and middle income, signed deals with the Chinese vaccine companies because they offered access when richer nations had claimed most of the doses made by Pfizer and Moderna. 
    • The delays in getting the Chinese vaccines and the fact that the vaccines are less effective mean that those countries may take longer to vanquish the virus.
    • State media has started a misinformation campaign against the American vaccines, questioning the safety of the Pfizer and Moderna shots and promoting the Chinese vaccines as a better alternative.
    • Sinopharm, a state-owned vaccine maker, and Sinovac have said they can produce up to a combined two billion doses this year, making them essential to the global fight against the coronavirus.
    • China’s campaign has been plagued with doubts, however. Many people have memories of the country’s vaccine scandals. 
    • Several governments remain angry about Beijing’s lack of openness about the virus in the early days of the pandemic.
    • A YouGov survey this month of roughly 19,000 people in 17 countries and regions showed that most were distrustful of a Covid-19 vaccine made in China. The misinformation campaign surrounding Western vaccines could further undermine its image.


Category 2: The Big Picture of the Digital Age

[genioux fact produced, deduced or extracted from NYT]

Type of essential knowledge of this “genioux fact”: Essential Deduced and Extracted Knowledge (EDEK).

Type of validity of the "genioux fact". 

  • Inherited from sources + Supported by the knowledge of one or more experts.


Authors of the genioux fact

Fernando Machuca


References




ABOUT THE AUTHORS

Sui-Lee Wee is a correspondent for The New York Times in the Beijing bureau. She has covered China for close to a decade and writes about social issues, gender, genetic surveillance, health care and the intersection of demographics and the economy.
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g-f(2)90 THE BIG PICTURE OF THE DIGITAL AGE, WSJ, Purchasing-managers surveys show American economy gaining momentum, risk of recession growing in Europe


VIRAL KNOWLEDGE: The “genioux facts” knowledge news




Extra-condensed knowledge

The U.S. economy picked up momentum at the start of the year, while Europe showed a growing risk of a second recession amid tougher restrictions to contain coronavirus infections, surveys of purchasing managers showed.
  • Part of the difference between the U.S. and European performance in January might be the result of more severe lockdowns that were imposed in Europe this month compared with the U.S., said Chris Williamson, chief business economist at IHS Markit.
  • The eurozone economy has suffered a weak start to the year, with high coronavirus infection rates and government restrictions increasing the risk of a second recession since the pandemic first struck last year.


Genioux knowledge fact condensed as an image


Category 2: The Big Picture of the Digital Age

[genioux fact produced, deduced or extracted from WSJ]

Type of essential knowledge of this “genioux fact”: Essential Deduced and Extracted Knowledge (EDEK).

Type of validity of the "genioux fact". 

  • Inherited from sources + Supported by the knowledge of one or more experts Supported by a survey.


Authors of the genioux fact

Fernando Machuca


References




ABOUT THE AUTHORS

Reporter, The Wall Street Journal


Kim Mackrael
Reporter, The Wall Street Journal
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Wednesday, December 30, 2020

g-f(2)54 MASTERING “THE BIG PICTURE OF THE DIGITAL AGE”: The categories of the “genioux facts”



Extra-condensed knowledge

  • A “genioux fact” belongs to one or more of the following categories:
    1. Category 1. A new, better world for everyone
    2. Category 2. The Big Picture of the Digital Age
    3. Category 3. The Big Picture of Sports
    4. Category 4. The Big Picture of coronavirus and other viruses
    5. Category 5. The Big Picture of Climate Change
  • The new world is in eternal construction. We have everything, the right science and technology, that we need to build a better world. We are hopeful that by mastering “The Big Picture of the Digital Age”, we can build a much better world for all.
  • “The Big Picture of Sports” teaches us that sports industries are very special growth engines.
    • The stars of these industries make millions of people dream.
    • These industries entertain while teaching winning multidisciplinary values, behaviors, strategies and knowledge.


Genioux knowledge fact condensed as an image


The “genioux facts” Knowledge Big Picture (g-f KBP) chart


Condensed knowledge 

  • A "genioux fact" is an executive block of essential knowledge with a unique identifier. 
  • A “genioux fact” belongs to one or more of the following categories:
    • Category 1. A new, better world for everyone
    • Category 2. The Big Picture of the Digital Age
    • Category 3. The Big Picture of Sports
    • Category 4. The Big Picture of coronavirus and other viruses
    • Category 5. The Big Picture of Climate Change
  • Category 1. A new, better world for everyone
  • Category 2. The Big Picture of the Digital Age
    • g-f(2)45 "The Big Picture of the Digital Age": Knowledge opens the way to staggering opportunities, risks and challenges. 
      • The Big Picture of the Digital Age can be synthesized with respect to the new knowledge that is produced as a simple but precious short story.
      • Every day we live an explosion of new FABULOUS knowledge in emerging technologies (e.g., AI, 5G, Robotics, Automation, IoT) and in multidisciplinary knowledge (e.g., Leadership, management, strategy, innovation, creativity, teamwork, organizational culture, marketing, resilience, uncertainty, disruptions, business models, supply chains, customer management) that best exploits those technologies and knowledge in general. 
      • Well-applied new knowledge leads to benefits of different kinds and scope for individuals, businesses, organizations, towns, cities, countries, and the world at large.
  • Category 3. The Big Picture of Sports
    • “The Big Picture of Sports” teaches us that sports industries are very special growth engines (g-f(3)1 Deloitte: 2020 Sports industry outlook).
      • The stars of these industries make millions of people dream.
      • These industries entertain while teaching winning multidisciplinary values, behaviors, strategies and knowledge.
      • These industries go a long way to reducing poverty, violence and terrorism.
  • Category 4. The Big Picture of coronavirus and other viruses
    • "The Big Picture of Coronavirus and Other Viruses" teaches us how to successfully deal with the complex risk of viruses.
    • National Geographic. There are more viruses than stars in the universe. More than a quadrillion quadrillion individual viruses exist on Earth, but most are not poised to hop into humans. Can we find the ones that are?
      • An estimated 10 nonillion (10 to the 31st power) individual viruses exist on our planet—enough to assign one to every star in the universe 100 million times over.
      • Viruses infiltrate every aspect of our natural world, seething in seawater, drifting through the atmosphere, and lurking in miniscule motes of soil. Generally considered non-living entities, these pathogens can only replicate with the help of a host, and they are capable of hijacking organisms from every branch of the tree of life—including a multitude of human cells.
  • Category 5. The Big Picture of Climate Change
    • NASA. Because of its unique “big picture” view of our planet, NASA is undertaking extensive research on climate change too. Using a fleet of cutting-edge satellites and teams of scientists working around (and off) the world, NASA is showing us what we can expect on a warming planet. 
      • Society depends on reliable, clean water supplies, but global warming is changing all that.
      • Measuring greenhouse gasses like carbon dioxide (CO2) in the atmosphere gives us the most reliable predictor of global warming. Throughout the earth’s history, CO2 and temperature rise and fall together. Today, humans are adding significant amounts of CO2 to the atmosphere by burning fossil fuels, jacking up the earth’s temperature. The Orbiting Carbon Observatory, launched in 2014, is measuring this CO2, giving us a better idea of the severity of the warming we can expect.
      • How many trees are we losing to deforestation? How much has sprawl eaten into our natural space? How long does it take for a forest to recover from a wildfire? What cities are most at risk from flooding? 

Category 2: The Big Picture of the Digital Age

[genioux fact produced, deduced or extracted from The knowledge of Fernando Machuca + “genioux facts” + National Geographic + NASA + Deloitte + MIT SMR + HBR + University of Oxford + MIT Sloan School of Management]

Type of essential knowledge of this “genioux fact”: Essential Solution Knowledge (ESK).

Type of validity of the "genioux fact". 

  • Inherited from sources + Supported by the knowledge of one or more experts + The research on the state of the art of “The Big Picture of the Digital Age”.


Authors of the genioux fact

Fernando Machuca


References





ABOUT THE AUTHORS

The director of "genioux facts" is the entrepreneur, researcher and professor Fernando Machuca (PhD with awarded honors in computer science in France) who has a disruptive proposal in the Digital Era to improve the world and reduce poverty + ignorance + violence. A critical piece of the solution puzzle is "genioux facts". The Innovation Value of "genioux facts" is exceptional for individuals, companies and any kind of organization.
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